abstract：:Neonatal lupus erythematosus (NLE) is associated with the transplacental passage of maternal anti-Ro and anti-La antibodies. In order to better determine the risk of delivery of a child with NLE, we examined the frequency of anti-Ro and anti-La antibody secreting cells in mothers of children with NLE and in mothers at...

journal_title：Journal of autoimmunity

authors： Isacovics B,Silverman ED

更新日期：1993-08-01 00:00:00

abstract：:Wegener's autoantigen (WA), a 29 kD multifunctional protein, is the principal target antigen of autoantibodies associated with Wegener's granulomatosis (WG). WA was first identified as proteinase 3 (PR3), which is now known to be identical with myeloblastin and AGP7. Like other lysosomal proteins, WA/PR3 displays enzy...

journal_title：Journal of autoimmunity

authors： Gross WL,Csernok E,Flesch BK

更新日期：1993-04-01 00:00:00

abstract：:Very little is known about the cellular immune response in c-ANCA (classical anti-neutrophil cytoplasm antibodies) positive vasculitides or Wegener's granulomatosis (WG). The present review is mainly based on published and unpublished observations of the Cattegat Study Group of Wegener's Granulomatosis. Immunohistoche...

journal_title：Journal of autoimmunity

authors： Rasmussen N,Petersen J

更新日期：1993-04-01 00:00:00

abstract：:Further to define the epitopes of PDC-E2, the major autoantigen in primary biliary cirrhosis (PBC), we have developed and characterized five human monoclonal antibodies. These antibodies were derived by fusing a regional hepatic lymph node from a patient with PBC with the mouse human heterohybrid cell line F3B6. Previ...

journal_title：Journal of autoimmunity

authors： Leung PS,Krams S,Munoz S,Surh CP,Ansari A,Kenny T,Robbins DL,Fung J,Starzl TE,Maddrey W

更新日期：1992-12-01 00:00:00

abstract：:Previous studies have indicated that blood mononuclear cells from 15-20% of patients with systemic lupus erythematosus (SLE) carry elevated levels of hsp90, a heat shock protein associated with steroid receptors in cells. We analysed surface expression of hsp90 on mononuclear cells (lymphocytes and monocytes) from pat...

journal_title：Journal of autoimmunity

authors： Erkeller-Yüksel FM,Isenberg DA,Dhillon VB,Latchman DS,Lydyard PM

更新日期：1992-12-01 00:00:00

abstract：:New Zealand (NZ) mouse strains comprise both autoimmune and non-autoimmune animals: NZ black (NZB) mice and the F1 hybrid (NZB/W) of NZB and NZ white (NZW) mice show spontaneous autoimmune disease by 6 months of age and die before the first year of age from renal disease, while NZW mice do not show autoimmune disorder...

journal_title：Journal of autoimmunity

authors： Esaguy N,Macedo PM,Castro AP,Aguas AP

更新日期：1992-10-01 00:00:00

abstract：:MIV-7 is a human monoclonal antibody that binds to DNA and carries a pathogenic anti-DNA idiotype 16/6. The antibody was generated by fusing peripheral blood lymphocytes of a healthy donor which were stimulated with an anti-idiotypic antibody to B11 (a human mAb anti-mouse mammary tumor virus-MMTV). The MIV-7, in addi...

journal_title：Journal of autoimmunity

authors： Blank M,Krause I,Ben-Bassat M,Shoenfeld Y

更新日期：1992-08-01 00:00:00

abstract：:Epitopes with linear sequences recognized by anti-La autoantibodies from seven mothers of children with congenital heart block were recently defined. Eight of these epitopes share sequence identity with three other proteins in addition to the original autoantigen, La. The three proteins are human cardiac myosin beta h...

journal_title：Journal of autoimmunity

authors： Horsfall AC,Rose LM

更新日期：1992-08-01 00:00:00

abstract：:Murine monoclonal antibodies (mAb) reacting with affinity-purified antihistone antibodies (AHA) from serum of a patient with systemic lupus erythematosus (SLE) were obtained. One of them, 8B3, was initially considered to recognize idiotypic (Id) determinants in AHA since (a) it reacted with AHA but not with control Ig...

journal_title：Journal of autoimmunity

authors： Subiza JL,Caturla A,Pereira LF,Camargo MC,Bustos A,Boimorto R,de la Concha EG

更新日期：1992-06-01 00:00:00

abstract：:This paper describes some of the methodological problems related to the measurement of cyclosporin. The clinical value of the measurements following organ transplantation are discussed and those areas also applying to autoimmune indications are highlighted. It is concluded that the routine use of cyclosporin monitorin...

journal_title：Journal of autoimmunity

authors： Holt DW,Johnston A

更新日期：1992-04-01 00:00:00

abstract：:There is now convincing evidence for the imposition of self-tolerance by means of the clonal deletion of self-reactive T cells operating within the thymus. Since not all self components may be encountered there, the question must be asked whether tolerance can occur post-thymically. To test this, we have used transgen...

journal_title：Journal of autoimmunity

authors： Miller JF

更新日期：1992-04-01 00:00:00

abstract：:The clinical manifestations of graft rejection or autoimmune disease represent the terminal phase in a complex sequence of inflammatory events. Although the spectrum of response to injury within each tissue is normally narrowly defined, the immune mechanisms involved may be heterogeneous, influenced by the immune stat...

journal_title：Journal of autoimmunity

authors： Keown PA

更新日期：1992-04-01 00:00:00

abstract：:There are two classes of autoimmune disease, organ-specific and non-organ specific or systemic. That cells producing autoantibodies are selected by antigen is strongly suggested by the presence of mutations and high affinity antibody. T-cells are pivotal in all forms of autoimmunity as evidenced by the therapeutic ben...

journal_title：Journal of autoimmunity

authors： Roitt IM,Hutchings PR,Dawe KI,Sumar N,Bodman KB,Cooke A

更新日期：1992-04-01 00:00:00

abstract：:A common epitope on S-antigen (arrestin), a potent autoantigen inducing experimental autoimmune uveoretinitis (EAU), and on human tumor necrosis factor alpha (hTNF alpha) was revealed using two monoclonal antibodies to S-antigen which inhibit EAU induction. The minimal common sequence for monoclonal antibody recogniti...

journal_title：Journal of autoimmunity

authors： Stiemer RH,Westenfelder U,Gausepohl H,Mirshahi M,Gundt A,Frank RW,Männel DN

更新日期：1992-02-01 00:00:00

abstract：:Different cell populations isolated from rats during the period of latency of adjuvant arthritis were injected into the bloodstream of naive rats to test their ability to transfer articular disorders. Synovium-derived cells (synoviocytes) were able to induce arthritis in 3 out of 4 recipient animals, whereas periphera...

journal_title：Journal of autoimmunity

authors： Ramos-Ruiz R,Bernabeu C,Ariza A,Fernández JM,Larraga V,López-Bote JP

更新日期：1992-02-01 00:00:00

abstract：:The effector mechanisms responsible for autoimmune beta cell destruction in insulin dependent (type 1) diabetes (IDD) remain elusive. In order to investigate whether T lymphocytes bearing the gamma-delta T cell receptor (gamma delta+ T cells) could be involved in this process, we measured percentages of peripheral blo...

journal_title：Journal of autoimmunity

authors： Lang FP,Schatz DA,Pollock BH,Riley WJ,Maclaren NK,Dumont-Driscoll M,Barrett DJ

更新日期：1991-12-01 00:00:00

abstract：:University of California at Davis line 200 (UCD-200) chickens develop a hereditary connective tissue disease characterized by severe lymphocytic infiltration, vascular occlusion and fibrosis of skin and internal organs. To identify cellular immunological abnormalities in the acute inflammatory disease stage of this an...

journal_title：Journal of autoimmunity

authors： Gruschwitz MS,Moormann S,Krömer G,Sgonc R,Dietrich H,Boeck G,Gershwin ME,Boyd R,Wick G

更新日期：1991-08-01 00:00:00

abstract：:Immunoblotting was optimized to detect autoantibodies to TSH receptors from human and porcine thyroid tissue and to determine their epitope specificity. Autoantibodies to putative TSH receptor proteins in thyroid particulate membranes were detected in approximately 35% of sera from patients with Graves' disease. Howev...

journal_title：Journal of autoimmunity

authors： Leedman PJ,Harrison PJ,Harrison LC

更新日期：1991-06-01 00:00:00

abstract：:Clinical course and changes in serum levels of antibodies to the acetylcholine receptor (a-AChR) were followed in 82 patients with myasthenia gravis during a period of 1-8 years after thymectomy. Decrease in a-AChR immediately after thymectomy was influenced by changes in a total IgG. Immunosuppressive medication affe...

journal_title：Journal of autoimmunity

authors： Kuks JB,Oosterhuis HJ,Limburg PC,The TH

更新日期：1991-04-01 00:00:00

abstract：:In some circumstances cyclosporine (CyA) induces autoimmune phenomena, and a lethal form of syngeneic graft-vs-host disease (SGVHD) can be induced in rats by the administration of CyA. Although several rat strains develop this disease, in this study, we report that of six mouse strains tested, only the DBA/2 strain de...

journal_title：Journal of autoimmunity

authors： Prud'homme GJ,Sanders R,Parfrey NA,Ste-Croix H

更新日期：1991-04-01 00:00:00

abstract：:IgA-, IgM- and IgG-containing immune complexes (CIC) were detected in 48, 19 and 12% of 52 patients with primary Sjögren's syndrome (SS), in 36, 38 and 56% of 45 patients with rheumatoid arthritis, and in 8, 5 and 3% of 40 normal controls. A high proportion of primary SS patients also had considerable amounts of serum...

journal_title：Journal of autoimmunity

authors： Bendaoud B,Pennec YL,Lelong A,Le Noac'h JF,Magadur G,Jouquan J,Youinou P

更新日期：1991-02-01 00:00:00

abstract：:Immunization with antigen-specific T cells has been used successfully in the treatment of several T cell-mediated experimental autoimmune diseases, including experimental allergic encephalomyelitis, thyroiditis, and adjuvant arthritis. The aim of this study was to determine whether T-cell vaccination could be used to ...

journal_title：Journal of autoimmunity

authors： Kahn CR,McIntosh KR,Drachman DB

更新日期：1990-12-01 00:00:00

abstract：:The BB rat spontaneously develops an insulin-dependent diabetes mellitus (IDDM) that closely resembles this disease in man. The pathogenesis involves autoimmune destruction of pancreatic islet beta-cells. In the present study, a single intraperitoneal injection of complete Freund's adjuvant (CFA) in diabetes-prone (DP...

journal_title：Journal of autoimmunity

authors： Sadelain MW,Qin HY,Sumoski W,Parfrey N,Singh B,Rabinovitch A

更新日期：1990-12-01 00:00:00

abstract：:The La antigen is a highly conserved protein, originally defined by sera of patients with Sjögren's syndrome or systemic lupus erythematosus (SLE). In the present study, we have produced and characterized a monoclonal anti-la antibody derived from mice with experimental SLE. The induction of SLE in these mice was achi...

journal_title：Journal of autoimmunity

authors： Offen D,Mendlovic S,Fricke H,Sperling R,Sperling J,Mozes E

更新日期：1990-12-01 00:00:00

abstract：:In a prospective study to evaluate the prevalence and predictive potential of circulating cytoplasmatic islet cell antibodies (ICA) and competitive insulin autoantibodies (CIAA), we screened 406 non-diabetic first-degree relatives of patients with Type I diabetes mellitus (n = 154 for CIAA). The prevalence of ICA was ...

journal_title：Journal of autoimmunity

authors： Ziegler AG,Baumgartl HJ,Standl E,Mehnert H

更新日期：1990-10-01 00:00:00

abstract：:Diabetes in the non-obese diabetic (NOD) mouse is a multigenic autoimmune disease and is possibly controlled by three recessive loci, including one that is linked to the major histocompatibility complex (MHC). The first external domain of the Class II MHC I-A beta chain in these mice is unique and has been suggested a...

journal_title：Journal of autoimmunity

authors： Singh B,Dillon T,Fraga E,Lauzon J

更新日期：1990-10-01 00:00:00

abstract：:Serum and Ig samples obtained from a patient with Graves' disease during exacerbation and remission were evaluated in the nu/nu bioassay. Blocking of the exacerbation serum's biological activity was demonstrated by several biological assay parameters after it was mixed with the remission serum. Since this blocking eff...

journal_title：Journal of autoimmunity

authors： Paschke R,Teuber J,Enger I,Schmeidl R,Schwedes U,Usadel KH

更新日期：1990-08-01 00:00:00

abstract：:Gm and Km allotypes were examined in 29 myasthenia gravis patients with a thymoma and non-receptor skeletal muscle antibodies. The frequency of the phenotype Gm1,2,3;23;5,21 was significantly higher in the patients than in 292 healthy controls (P less than 0.01). Km allotype frequencies did not differ in patients and ...

journal_title：Journal of autoimmunity

authors： Gilhus NE,Pandey JP,Gaarder PI,Aarli JA

更新日期：1990-06-01 00:00:00

abstract：:Systemic Lupus Erythematosus (SLE) is a multisystem disease characterized by an increase in the secretion of autoantibodies. The mechanisms of autoantibody-induced disease have not been clarified. 1,25-Dihydroxy-vitamin D3 (1,25-D3) is known to be important in the regulation of normal human lymphocyte functions. Among...

journal_title：Journal of autoimmunity

authors： Chong PJ,Matzner WL,Wallace DJ,Klinenberg JR,Toyoda M,Jordan SC

更新日期：1989-12-01 00:00:00

abstract：:The serum concentrations of IgM, IgG1, IgG2b, IgG3 and IgA were determined in mice of C57BL/6 background, from weaning to one year of age, by quantitative isotype-specific, indirect double sandwich enzyme-linked immunosorbent assays (ELISAs). Only limited data could be obtained for the IgG2a isotype in the present stu...

journal_title：Journal of autoimmunity

authors： Klein-Schneegans AS,Kuntz L,Fonteneau P,Loor F

更新日期：1989-12-01 00:00:00

abstract：:Eight patients with arthritis (seven with rheumatoid, one with psoriatic arthritis) were treated for 7 d with a daily injection of 10 mg of mouse monoclonal anti-CD4 antibodies (three with VIT4, five with MT151). With the exception of a short-lasting low-grade fever in one patient, no side effects were observed. Clini...

journal_title：Journal of autoimmunity

authors： Herzog C,Walker C,Müller W,Rieber P,Reiter C,Riethmüller G,Wassmer P,Stockinger H,Madic O,Pichler WJ

更新日期：1989-10-01 00:00:00

abstract：:To investigate patterns of autoreactivity in Sjögren's syndrome, the epitope specificity of anti-La antibodies was determined using recombinant antigens bearing sequences of the amino, middle, and carboxyl portions of the La molecule. Sera from patients with primary as well as secondary Sjögren's syndrome reacted with...

journal_title：Journal of autoimmunity

authors： St Clair EW,Talal N,Moutsopoulos HM,Ballester A,Zerva L,Keene JD,Pisetsky DS

更新日期：1989-08-01 00:00:00

abstract：:It has been recently suggested that primary Sjögren's syndrome (SS) patients present with a variety of personality structure disturbances and psychiatric symptoms. To evaluate this finding further, we assessed hostility structure and psychiatric symptoms in 33 Sjögren's syndrome patients and compared the results with ...

journal_title：Journal of autoimmunity

authors： Drosos AA,Angelopoulos NV,Liakos A,Moutsopoulos HM

更新日期：1989-08-01 00:00:00

abstract：:Sjögren's syndrome (SS) is an autoimmune disease with a predisposition to transform into a B-cell lymphoma. Stable B-cell lines were established (without exogenous stimulation other than fetal bovine serum) from the peripheral blood of three SS patients. These cell lines secreted immunoglobulin (either IgG, IgM or bot...

journal_title：Journal of autoimmunity

authors： Takei M,Dang H,Dauphinée MJ,Talal N

更新日期：1989-08-01 00:00:00

abstract：:In a proliferation assay, peripheral blood lymphocytes (PBL) from a relatively small proportion of myasthenia gravis (MG) patients and from controls responded to Torpedo acetylcholine receptor (T-AChR), which shows approximately 75% homology with the human AChR. Over 50% of MG patients responded to recombinant human A...

journal_title：Journal of autoimmunity

authors： Newsom-Davis J,Harcourt G,Sommer N,Beeson D,Willcox N,Rothbard JB

更新日期：1989-06-01 00:00:00

abstract：:Interleukin-2 (IL-2) gene regulation was investigated in primary cultures of highly purified human peripheral blood CD28+ T cells. Two discrete mechanisms for induction of T-cell proliferation could be distinguished by examining cell cycle progression and the expression of the IL-2 gene. Stimulation of cells by CD3 Mo...

journal_title：Journal of autoimmunity

authors： June CH,Jackson KM,Ledbetter JA,Leiden JM,Lindsten T,Thompson CB

更新日期：1989-06-01 00:00:00

abstract：:An experimental model of two interacting clones of T cells is described, which may be used for defining and exploring the T-cell immunoregulatory network. Mx9/9 is a CD4 clone bearing an antigen receptor recognized by the Mx9 anti-V beta 8 monoclonal antibody (MoAb). Anti-V beta 8 MoAbs activate and induce cell prolif...

journal_title：Journal of autoimmunity

authors： Naor D,Essery G,Kahan M,Feldmann M

更新日期：1989-06-01 00:00:00

abstract：:Physiologically, HLA Class II molecules are primarily expressed on immunoregulatory cells. In recent years, it has been shown that tissues affected by autoimmunity, including beta cells of 'diabetic' pancreases, 'inappropriately' express these glycoproteins. Cytokines are potent Class II inducers on a variety of cells...

journal_title：Journal of autoimmunity

authors： Pujol-Borrell R,Soldevila G,Buscema M,Vives M,Badenas J,Marakian R,Bottazzo GF

更新日期：1989-06-01 00:00:00

abstract：:Spontaneous idiotype shift of anti-DNA antibodies in systemic lupus erythematosus was shown to be associated with changes in the clinical manifestations of the disease. Characterization of two anti-DNA antibody preparations from the same lupus patient showed that lupus nephritis was associated with antibodies showing ...

journal_title：Journal of autoimmunity

authors： Suenaga R,Munoz PA,Hon SH,Abdou NI

更新日期：1989-06-01 00:00:00

abstract：:Class II antigens of the major histocompatibility complex (MHC) have a well-defined role in restricting cellular interactions and presenting processed antigen to T cells. In addition, a fundamental role for Class II antigens in cellular activation has been suggested, following studies demonstrating that Class II antig...

journal_title：Journal of autoimmunity

authors： Mooney N,Grillot-Courvalin C,Hivroz C,Charron D

更新日期：1989-06-01 00:00:00